While reviewing a fascinating figure from Cell Science , Ghost came across an opportunity to discuss the tumor microenvironment (TME)—a...

While designing a model to describe a patient's immuno-oncology (IO) status, Ghost encountered a significant dimension reduction problem....

First things first, the proposed classification are immune suppressing and immune escaping. Now let's go back for some specifics....

Immunotherapy has been the hot spot in cancer treatment in recent years. As a key component, neoantigen identification is usually done...

Tumor clonal evolution Cancer is stubborn largely due to its nature of heterogeneity: they evolve to adjust the changes of surrounding...

Identifying somatic mutation has always been challenging. Tumor heterogeneity The major challenge of calling somatic mutation is...

Frequentist's approach: Assume sequencing error distribution. Frequentist's method makes the null hypothesis that non-reference allele is...

Ghost wrote a blog regarding tumor CNV calling with matched normal earlier. Here let's talk about what we can do when matched normal is...

Deep learning has been the hot spot in recent years and shown excellent performance in many applications. In bioinformatics, Google has...

For people who have tried to build an oncology database or automated pipeline, one of the task is to define a standardized cancer type...